Kuo-Lung Ku
Title： Professor
Education： Ph.D., National Taiwan University (1992)
Research Area： Bio-Analytical Chemistry
Tel: 886-5-271-7405 e-mail: klku@mail.ncyu.edu.tw
Research Interests：      My research interest has been focused on analytical method development for searching for bioactive compounds from bio-natural sources. The ongoing project s i ncluding developing an analytical method by using HPLC coupled with enzyme reaction for determination of antioxidants in plants, developing a peptide analysis system for fungi infected insects by using LC and ESI-ion trap mass, developing ESI-MS methods for analysis of bioactive compounds (antioxidants, ant tumor agents, peptides and proteins), developing plant tissue culture system for production of stil benoids , especially for piceatannol and resveratrol.
Publications：

1.       古國隆、黃慧中 、廖宇賡(2014) 加州藜蘆癒傷組織及類根莖體之誘導及其環巴胺含量分析。作物、環境與生物資訊. 11 : 243-256

2.       D-L M. Tzou, L-K Ni, M-M Chen, M-C Chiou, L-C Chen, S-T Hsu, K-L Ku*, C-C Cheng (2013) Fingerprints of Phalaenopsis Tissues in Growth and Spike Induction Periods—A Solid-state 13C NMR Approach. Journal of the Chinese Chemical Society. 60 : 1107-1112

3.       Ku, K.-L. *; Yeh, W.-H.; Liao, Y.-K (2013) Induction of in vitro Cultured Hairy Roots of Vitis thunbergii Sieb. and Zucc. and trans-Resveratrol Production. Quarterly Journal of Chinese Forestry. 46 : 255-274

4.       Wen Yu Hsiao, Kuo Long Ku*, Yih Ming Weng (2013) Antioxidant activity and contents of total phenolic,monacolin K, GABA and citrinin of Monascus-fermented soy sauce. Advanced Materials Research 807 : 2066

5.       Wen Yu Hsiao, Kuo Long Ku*, Yih Ming Weng (2013) Physicochemical characteristics of Monascus-fermented soy sauce. Advanced Materials Research. 807 : 2059-2065

6.       Huang, H,-F.; Ku, K.-L.* (2013) The Study of Matrix Effects between Nickel and Vanadium in Solvent Systems by ICP-OES. CHEMISTRY (The Chinese Chemical Society, Taipei) 71:183-192

7.       Liao, C.-I; Ku, K.-L.* (2012) Development of a Signal-Ratio-Based Antioxidant Index for Assisting the Identification of Polyphenolic Compounds by Mass Spectrometry. Anal. Chem. 84: 7440-7448. (SCI)

8.       Weng, S.-S.; Ku, K.-L.; Lai, H.-T. (2012) The Implication of Mediators for Enhancement of Laccase Oxidation of Sulfonamide Antibiotics. Bioresource Technology 113: 259-264. (SCI)

9.       Ku, K.-L.; Hsu, C.-F.; Liao, Y.-K. (2012) Production of Acteoside in Hairy-Root Culture of Paulownia fortunei Hemsl. Taiwan J. For. Sci. 27: 13-29. (EI)

10.    李秋慧，古國隆，劉景平* (2011) 儲存條件及時間對胡麻（Sesamum indicum L.）油主要香氣揮發物質含量之影響。J. Agric. For. (NCYU). 8: 73-85.

11.    Jan, K.-C.; Ku, K.-L.; Chu, Y.-H.; Hwang, L. S.; Ho, C.-T. (2011) Intestinal Distribution and Excretion of Sesaminol and Its Tetrahydrofuranoid Metabolites in Rats. J. Agric. Food Chem. 59: 3078-3086. (SCI)

12.    Liao, C.-I; Ku, K.-L. (2012) Development of a Signal-Ratio-Based Antioxidant Index for Assisting the Identification of Polyphenolic Compounds by Mass Spectrometry Anal. Chem. 84: 7440-7448. (SCI)

13.    Ku, K.-L.; Hsu, C.-F.; Liao, Y.-K. (2012) Production of Acteoside in Hairy-Root Culture of Paulownia fortunei Hemsl.Taiwan J. For. Sci. 27: 13-29.

14.    Weng, S.-S.; Ku, K.-L.; Lai, H.-T. (2012) The Implication of Mediators for Enhancement of Laccase Oxidation of Sulfonamide Antibiotics. Bioresource Technology 113: 259-264. (SCI)

15.    Jan, K.-C.; Ku, K.-L.; Chu, Y.-H.; Hwang, L. S.; Ho, C.-T. (2011) Intestinal Distribution and Excretion of Sesaminol and Its Tetrahydrofuranoid Metabolites in Rats. J. Agric. Food Chem. 59: 3028-3086. (SCI)

16.    Yang, M.-H.; Kuo, C.-H.; Hsieh, W.-C.; Ku, K.-L.* (2010) Investigation of Microbial Elicitation of trans-Resveratrol and trans-Piceatannol in Peanut Callus Led to the Application of Chitin as a Potential Elicitor. J. Agric. Food Chem. 58: 9537-9541. (SCI)

17.    Yang, M.-H.; Lin, Y.-J.; Kuo, C.-H.; Ku, K.-L.* (2010) Medicinal Mushroom Ganoderma lucidum as a Potent Elicitor in Production of t-Resveratrol and t-Piceatannol in Peanut Calluses. J. Agric. Food Chem. 58: 9518-9522. (SCI)

18.    Jan, K.-C.; Ku, K.-L.; Chu, Y.-H.; Hwang, L.-S.; Ho, C.-T. (2010) Tissue Distribution and Elimination of Estrogenic and Anti-Inflammatory Catechol Metabolites from Sesaminol Triglucoside in Rats. J. Agric. Food Chem. 58: 7693-7700. (SCI)

19.    Fang, C.-J.; Ku, K.-L.; Lee, M.-H.; Su, N.-W. (2010) Influence of nutritive factors on C₅₀ carotenoids production by Haloferax mediterranei ATCC 33500 with two-stage cultivation. Bioresour. Technol. 101: 6487-6493  (SCI)

20.    Chen, Y.-J., Tsai, Y.-M., Kuo, C.-D., Ku, K.-L., Shie, H.-S., Liao, H.-F.* (2009) Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect. Life Sciences. 85: 642-651 (SCI)

21.    謝琬菁，郭章信，張平順，劉景平，古國隆* (2009) 細菌與真菌對落花生生成植物防禦素之影響 – 以 AHX TN14 菌及 Botryodiplodia theobroma (LBBT HC6-1) 對比杉特醇及白藜蘆醇生成之影響。J. Agric. For. (NCYU). 6: 1-12

22.    林羿汝，郭章信，張平順，劉景平，古國隆* (2009) 兩種誘引劑對落花生癒合組織產生類二苯乙烯之影響。J. Agric. For. (NCYU). 6: 13-28

23.    Ku, K.-L.; Tsai, C.-T.; Chang, W.-M.; Shen, M.-L.; Wu, C.-T.; Liao, H.-F. (2008) Hepatoprotective Effect of Cirsium arisanense Kitamura in Tacrine-Treated Hepatoma Hep 3B Cells and C57BL Mice. Am J Chin Med. 36: 355-368 (SCI)

24.    林宜昕，古國隆，邱垂豐，劉景平* (2008) 大葉種茶樹不同品種、採摘時期及葉位對茶多元酚含量之影響。J. Agric. For. (NCYU). 5: 15-31

25.    鄭雅今，古國隆* (2007) 質譜在植物防禦素研究上之應用。CHEMISTRY (The Chinese Chemical Society, Taipei). 65: 157-167.

26.    Lin, L-L.; Lien C.-Y.; Cheng, Y.-J.; Ku, K.-L.* (2007) An Effective Sample Preparation Approach for Screening the Anticancer Compound Piceatannol Using HPLC Coupled with Fluorescence Detection. J. Chromatogra. B. 853: 175-182. (SCI)

27.    Ku, K.-L.; Chiou, J.-L.; Liu, F.-C.; Chiou, R. Y.-Y. (2007) Advanced gas chromatographic-mass spectrometric studies for identification of the cellular octadecenoate isomers and changes of fatty acid composition induced by ethanol stressin Escherichia coli and Escherichia coli O157:H7. J. Food Protec. 70: 616-622. (SCI)

28.    Yao, Y.-F.; Weng, Y.-M.; Hu, H.-Y.; Ku, K.-L.; Lin, L.-L. (2006) Expression optimization and biochemical characterization of a recombinant γ-glutamultranspeptidase from Escherichia coli novablue. The Protein J. 25: 431-441. (SCI)

29.    Ku, K.-L.*; Chang, P.-S.; Cheng, Y.-C.; Lien, C.-Y. (2005) Production of stilbenoids from the callus of Arachis hypogaea: a novel source of the anticancer compound piceatannol. J. Agri. Food Chem. 53: 3877-3881. (SCI)

30.    Hua, Y.-W.; Chi, M.-C.; Lo, H.-F.; Kuo, L.-Y.; Ku, K.-L.; Lin, L.-L. (2005) Adsorption-elution purification of chimeric Bacillus stearothermophilus leucine aminopeptidase II with raw-starch-binding activity. World J. Microbio. Biotech. 21: 689-694. (SCI)

31.    Yang, C.-S.; Ku, K.-L. (2004) Thermodynamic-dependent size-selection of ZnSe nanopatricles in amphiphilic triblock copolymer systems. J. Chin. Chem. Sic. 51:65-70. (SCI)

32.    Yang, C.-S.; Ku, K.-L. (2003) Synthesis and organization of II-VI low dimension nanomaterials in nonionic amphiphilic triblock copolymer systems. Inter. J. Nanosci. 2:257-263.(SCI)

33.    Lin, L.-L.; Lo, H.-F.; Chi, M.-C.; Ku, K.-L. (2003) Functional expression of the raw starch-binding domain of Bacillus sp. TS-23 α-amylase in recombinant Escherichia coli. Starch/Stärke 55: 197-202. (SCI)

34.    Lo, H.-F.; Chen, J.-N.; Ku, K.-L.; Hsu, W.-H. (2002) Recovery of a recombinant Bacillus sp. TS-23-amylase by adsorption-elution on raw starch. Starch/Stärke 54: 338-342. (SCI)

35.    Chiou, Robin Y.-Y.; Ku, K.-L.; Chang, L.-G.(2001) Antioxidation characteristics of oils in the ground pork-fat patties after cooked with soysauce. J. Am. Oil Chem. Soc. 78: 7-11. (SCI)

36.    Ku, K.-L.; Chen, T.-P.; Chiou, Robin Y.-Y. (2000) Apparatus used for small-scale volatile extraction from ethanol-supplemented low-salt miso and GC-MS characterization of the extracted flavors.  J. Agri. Food Chem., 48(8): 3507-3511. (SCI)

37. 柳煌，鍾玉明，蘇南維，王美玲，古國隆，李敏雄 (1999) 矽膠管柱快速層析區分椪柑皮自體酵素作用精油之研究。中國農化會誌。37: 276-288。

38.    李敏雄，柳煌，蘇南維，古國隆，鍾玉明 (1999) 柑橘皮自體酵素對精油中d-Limonene 轉換作用之研究。中國農化會誌。37: 1-19

39.    Ku, K. -L.; Lee, R. -S.; Young, C.T.; Chiou, Robin Y. -Y. (1998) Roasted peanut flavor and related compositional characteristics of peanut kernels of Spring and Fall crops grown in Taiwan. J. Agri. Food Chem., 46: 3220-3224. (SCI)

40.    Chiou, Robin Y. -Y.; Ku, K. -L.; Chen, W. –L. (1997) Compositional characterization     of peanut kernels after subjection to various germination times. J. Agri. Food Chem., 45: 3060-3064. (SCI)